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ÎÄÏ×Ãû³Æ£ºAlogliptin, a Dipeptidyl Peptidase©\4 Inhibitor, Alleviates Atrial Remodeling and Improves Mitochondrial Function and Biogenesis in Diabetic Rabbits
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DOI:10.1161/JAHA.117.005945
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Serum biochemical examination including fasting glucose at the 8th week, total cholesterol, triglycerides, low©\density lipoprotein cholesterol, high©\density lipoprotein cholesterol, and creatinine level were detected using a full automatic biochemical analyzer. Fasting insulin and GLP©\1 level were assessed using a rabbit insulin ELISA kKit (Wuhan Huamei Biological Engineering Co, Ltd) and rabbit GLP©\1 ELISA kit (Shanghai Huding Biological Technology Co) according to the manufacturers' instructions, respectively. A lipid peroxidation malondialdehyde (MDA) assay kit (Nanjing Jianchen Bioengineering Institute) was used to detect the serum MDA level, and another oxidative stress–related marker serum 8©\hydroxy©\2′©\deoxyguanosine (8©\OHdG) was assessed by a rabbit 8©\OHdG ELISA kit (Shanghai Huding Biological Technology Co). Serum antioxidant enzyme superoxide dismutase activity was evaluated by an antioxidant enzyme activities kit (Nanjing Jianchen Bioengineering Institute). Finally, the inflammation marker high©\sensitivity C©\reactive protein level was also detected using a rabbit high©\sensitivity C©\reactive protein ELISA kit (Wuhan Huamei Biological Engineering Co, Ltd).